Page 21 - AWA-41-No.1 issue

DAIRY FARMING

liBond® improved colostrum yield and ZIVO Bioscience Active Ingredients in the Battle
increased energy corrected milk (ECM)
in the first 15 weeks of lactation, without Against Avian Influenza
affecting dry matter intake (DMI) post- ivo Bioscience, Inc. a pioneering
partum. Cows that received hydroxy Zbiotech/agtech R&D company dedi-
trace minerals also performed better in cated to developing therapeutic, medici-
terms of disease incidence, which led nal and nutritional product candidates
to lower culling rates and better fertil- derived from proprietary algal cultures,
ity (more cows pregnant at 305 days in reports favorable results from a study con-
milk DIM)), compared to the cows that ducted in collaboration with the Universi-
ty of Delaware that evaluated the potential
received sulphate-based trace minerals.
of ZIVO’s proprietary active ingredients to
Using Selko® IntelliBond® hydroxy reduce the transmission of Low Pathoge- ing that an optimal product configuration
trace minerals (Zn, Cu and Mn) also in- nicity Avian Influenza (LPAI) virus among could provide more comprehensive pro-
fluence methane emissions, one of the poultry. tection. The study’s positive outcomes jus-
tify further research and product develop-
most important parameters in dairy sus- Key findings of statistical significance ment, supporting the potential of ZIVO’s
tainability. This study presented at Dairy- from the study include: pipeline to address both LPAIV infections
NutriVision showed that hydroxy trace • A reduction in viral titers (viral shed- as well as a broad spectrum of other viral
minerals improved in vitro fermentation ding) in infected birds receiving ZIVO’s challenges faced by the poultry industry.
parameters of apparent Organic Matter products compared with untreated infect-
Disappearance (aOMD) and Apparent ed controls. “We are highly encouraged by the out-
Microbial Biomass Production (aMBP; comes of this study,” said John B. Payne,
Chairman and CEO of ZIVO Bioscience.
• A delay in transmission of LPAI when
proxy for milk production) compared healthy birds were exposed to infected “The University of Delaware’s findings
to other trace mineral sources. This im- birds, suggesting a slower and less ag- provide compelling evidence that our
provement in rumen fermentation in the gressive spread of disease. feed ingredients could be valuable tools
hydroxy trace mineral group led to a in mitigating the risk of avian influenza
decreased release of methane per unit The two-part controlled study evaluated outbreaks without the limitations asso-
of aOMD. Earlier, an independent verifi- the efficacy of ZIVO’s proprietary active ciated with vaccines. Reducing disease
ingredients, previously shown to be effi-
cation of an LCA evaluating the ability of cacious for mitigating the effects of coc- transmission can positively impact both
Selko® IntelliBond® to reduce the cow’s cidiosis in broiler chickens, against LPAI. animal welfare and the operations of pro-
carbon footprint showed that it can re- ducers. These study results represent a
duce the cow’s carbon footprint by up to In the first part of the study, infected significant milestone in our efforts to de-
2%, compared to sulphate-based trace birds receiving a mixture of ZIVO’s pro- liver science-driven, sustainable solutions
prietary active ingredients showed an
minerals. to address serious challenges facing the
early significant decrease in viral titers global poultry industry.”
Conclusion compared with untreated, infected con-
trols, thereby reducing amount of detect- “This study sponsored by ZIVO Biosci-
For successful dairy production, it is im- able virus that was shed. At the end of the ence enabled us to evaluate novel inter-
portant to ensure the right nutrients and/ study, although not significant in nature, a ventions to provide immune support for
or additives are present at the right time numerical decrease in virus was noted in poultry,” said Brian Ladman, Ph.D., Princi-
to support optimised productivity, health birds receiving ZIVO’s product. In the sec- pal Investigator at the University of Dela-
and well-being, cost-effectiveness and ond part, healthy chickens were housed ware’s Department of Animal and Food
environmental sustainability. Supple- with infected birds, replicating a real- Sciences. “The findings demonstrate that
mentation with a quality source of trace world, high-risk environment for disease further investigation into ZIVO’s active
minerals is required to keep dairy cows transmission. Compared to an untreated ingredients to safeguard poultry flocks
control group, birds that received ZIVO’s
healthy and productive. An increasing proprietary active ingredients that were against viral outbreaks is warranted. I
amount of research is now available to housed with infected birds experienced look forward to continuing to work with
ZIVO to identify novel solutions to this
allow us to choose the most effective a statistically significant delay in viral critical public health issue.”
source while fine-tuning recommenda- detection. This observed delay suggests
tions and feeding strategies. that ZIVO’s products limit viral replication “With these preliminary efficacy re-
within a host. sults, we are now planning additional
Selko and Trouw Nutrition are at the studies to further evaluate the benefits of
forefront in dairy cow nutrition, providing These favorable results indicate that our products. We are at a critical point in
cutting edge research and application of ZIVO’s proprietary active ingredients rep- our mission to find a viable treatment for
its highly effective hydroxy trace miner- resent potential preventative measures avian influenza, and the need for an effec-
als. At DairyNutriVision, some of these for reducing the spread of LPAIV in com- tive therapy grows every day,” said John
recent insights were shared with a global mercial poultry operations and enhancing Payne. “We will continue towards com-
overall flock health.
audience, leading to better understand- mercialization of our coccidiosis treat-
ing of trace mineral nutrition and the use Multiple products were explored to iden- ment while utilizing these preliminary re-
of trace minerals, a crucial part in our tify the most effective strategies against sults to further our partnership dialogues.
quest to building the sustainable dairy LPAI. While some products were better at I am confident that ZIVO can take the
cow of the future. lowering the viral titer, others were more next step toward evaluating this potential
effective at slowing the spread, suggest- breakthrough technology.”
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Vol. 41 No. 1 19